The sdAb-DB team would like to encourage sdAb researchers to deposit their sequences and become part of the sdAb-DB community. We would like to provide the community with the sequence and experimental data required for further bioinformatic analysis and bioengineering of sdAbs, leading to the development of well-characterized sdAbs with a wide range of functionalities.
The Single Domain Antibody Database was envisioned by Dr. Hans-Joachim Wieden, a Professor at the University of Lethbridge, and the 2016 University of Lethbridge Collegiate iGEM team. It has been developed by Michael Opyr, Emily Wilton, Dr. Senthil Kumar Duraikannu Kailasam and Dr. Andrew Hudson, with assistance from Ronja Kothe.
Dr. Wieden is the director of the Alberta RNA Research and Training Institute (ARRTI) and the Director of SynBridge, a synthetic biology makerspace, both headquartered at the University of Lethbridge.
University of Lethbridge campus
The Alberta RNA Research and Training Institute (ARRTI) is an RNA-focused research centre that uses mainly biophysical and engineering approaches in the study of structure and function of RNA-based cellular systems.
ARRTI is dedicated to foster and facilitate RNA research and training excellence, to contribute to the multidisciplinary research and teaching community at the University of Lethbridge, its surrounding communities and beyond, ultimately facilitating transfer of leading-edge knowledge into the private sector as well as academia.
ARRTI consists of eight University of Lethbridge researchers, who apply a wide range of multidisciplinary approaches to study the structure and function of RNA, and currently has over 70 trainees, from undergraduate to postdoctoral.
SynBridge is a supervised synthetic biology makerspace that also serves as a core research facility at the University of Lethbridge, being overseen and operated by the Alberta RNA Research and Training Institute.
SynBridge will empower interested students, graduates, post-doctorate students and faculty to explore their creativity and ideas by providing access to infrastructure that otherwise would not be available to them, and will promote entrepreneurship by reducing the technological and financial barriers to bring synthetic biology / bio-engineering ideas to the point where commercialization is possible.
Wilton, E.E., Opyr, M.P., Kailasam, S., Kothe, R.F. and Wieden, H.-J.* (2018)
sdAb-DB: The Single Domain Antibody Database.
ACS Synthetic Biology 7(11): 2480-2484. DOI: 10.1021/acssynbio.8b00407